Metabolically Healthy Obesity- A comprehensive review
Metabolically healthy obesity (MHO) is a concept derived from clinical observations that a subgroup of people with obesity do not exhibit overt cardiometabolic abnormalities.

Although there is no standardized definition of MHO, the following criteria have been proposed in addition to the diagnosis of obesity (BMI ≥30 kg/m2): fasted serum triglycerides ≤1.7 mmol/l (≤150 mg/dl); HDL cholesterol serum concentrations >1.0 (>40 mg/dl) (in men) or >1.3 mmol/l (>50 mg/dl) (in women); systolic blood pressure (SBP) ≤130 mmHg; diastolic blood pressure ≤85 mmHg; fasting blood glucose ≤ 6.1 mmol/l (≤100 mg/dl); no drug treatment for dyslipidemia, diabetes, or hypertension; and no cardiovascular disease manifestation.

With an age- and gender-dependent prevalence between ~10% to 30%, MHO is not a rare condition. Individuals with MHO are characterized by lower liver and visceral fat, but higher subcutaneous leg fat content, greater cardiorespiratory fitness and physical activity, insulin sensitivity, lower levels of inflammatory markers, and normal adipose tissue function compared to patients with metabolically unhealthy obesity (MUO).

Metabolically healthy obesity most likely represents a transient phenotype, and individuals with MHO still have an indication for weight-loss interventions because their risk of developing cardiometabolic diseases may be lower compared to MUO, but it is still higher than in metabolically healthy lean people.

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