Metastatic malignant melanoma of unknown primary site to the
The natural history of metastatic melanoma in the absence of a known primary site has been poorly defined. The disease usually presents a significant cause of morbidity and mortality. Around 90% of melanomas have a cutaneous origin, but still, there are melanomas that could be found in visceral organs or lymph nodes with the unknown primary site. Spontaneous regression of the primary site could be an explanation. The disease is frequently diagnosed after treatment for known extracranial metastases and has a poor outcome despite various local and systemic therapeutic approaches.

Most patients with brain metastases from malignant melanoma are diagnosed after treatment for known extracranial metastases and have a poor outcome despite various local and systemic therapeutic approaches. Metastatic melanomas of the brain with unknown primary present significant morbidity and mortality and confer a poor prognosis. Delay in diagnosis and treatment is of serious concern when it comes to improve the prognosis of patients with this disease. The optimal treatment depends on the objective situation, often surgery, radiosurgery, whole-brain radiotherapy, and chemotherapy can be used in combination to obtain longer remissions and optimal symptom relief.

Source:https://www.sciencedirect.com/science/article/pii/S2210261221008130
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