Metformin-Induced Changes on BMI, TSH, and Thyroid Hormones
Polycystic ovary syndrome (PCOS) is one of the most common hormonal and metabolic disorders that affects approximately 5-10% of reproductive-aged women and 20.5-24.5% of 15-19 year-old girls. The prevalence of this heterogeneous clinical disorder is likely increasing because obesity and insulin resistance (IR), as the most important etiological factors of PCOS, have dramatically increased in this population. This multigenic syndrome is characterized by clinical or biochemical hyperandrogenism, chronic anovulation, irregular menstruation, pregnancy loss, and infertility resulting in oligo- or amenorrhoea. The prevalence of this heterogeneous clinical disorder is likely increasing because obesity and insulin resistance (IR), as the most important etiological factors of PCOS, have dramatically increased in this population. This multigenic syndrome is characterized by clinical or biochemical hyperandrogenism, chronic anovulation, irregular menstruation, pregnancy loss, and infertility resulting in oligo- or amenorrhoea...

http://www.omicsonline.org/open-access/the-metformininduced-changes-on-bmi-tsh-and-thyroid-hormones-profileof-patients-with-polycystic-ovarian-syndrome-2161-038X-1000191.php?aid=79613
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