Metformin versus Placebo in Obese Pregnant Women without Dia
A double-blind, placebo-controlled trial, where we randomly assigned pregnant women without diabetes who had a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of more than 35 to receive metformin, at a dose of 3.0 g per day, or placebo (225 women in each group) from 12 to 18 weeks of gestation until delivery...

http://www.nejm.org/doi/full/10.1056/NEJMoa1509819#t=articleTop
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