Microclots In Blood Can Explain Lingering Symptoms In Long C
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A new study has shown that overload of various inflammatory molecules, trapped inside insoluble microscopic blood clots can be the cause of some of the lingering symptoms experienced by individuals with long Covid. Researchers say that with high levels of alpha(2)-antiplasmin in the blood of Covid-19 patients and individuals suffering from long Covid, the body's ability to break down the clots are significantly inhibited. They used techniques including proteomics and fluorescence microscopy to study plasma samples from healthy individuals, individuals with Type 2 Diabetes Mellitus (T2DM), with acute COVID-19, and those with Long COVID/PASC symptoms. Findings showed tha microclots in both acute COVID-19 and Long COVID/PASC plasma samples are resistant to fibrinolysis (compared to plasma from controls and T2DM), even after trypsinisation. Also, they detected various inflammatory molecules that are substantially increased in both the supernatant and trapped in the solubilized pellet deposits of acute COVID-19 and Long COVID/PASC, versus the equivalent volume of fully digested fluid of the control samples and T2DM. This implies that the plasmin and antiplasmin balance may be central to pathologies in long Covid. Further research is needed to understand clotting and fibrinolytic system function in individuals with lingering long Covid symptoms.

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