Minocycline Black Bone disease in Arthroplasty found to be a
Prolonged Minocycline use can cause selective staining of subchondral bone, whilst peri-articular soft tissue and cartilage appear uninvolved. Minocycline black bone disease is a rare finding that can cause concern when unexpectedly encountered during routine Arthroplasty.

A systematic review according to PRISMA guidelines was performed to identify all the reported cases in the literature.

--11 cases of minocycline black bone disease encountered during arthroplasty have been reported in the literature.

--All cases have had an excellent outcome, with no complications reported to date.

In conclusion, Minocycline black bone disease can be a serious intra-operative finding when discovered unexpectedly during routine arthroplasty, but it should not influence the surgical plan. When the history is uncertain, surgeons should rule out other causes of bone discoloration.

Source: https://josr-online.biomedcentral.com/articles/10.1186/s13018-021-02617-w