Minocycline-induced hyperpigmentation of the skin, sclera, a
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Minocycline has long been used to treat a number of conditions. It is frequently prescribed on a long-term basis to treat acne vulgaris or for the management of patients with a prosthetic joint infection. Adverse effects of extended minocycline use (>3 months) include hyperpigmentation of various bodily tissues, including ocular tissue, which one of the few causes of “blue sclera.” The drug’s effects on the conjunctiva and retina are much rarer and not as widely known.Hyperpigmented conjunctival cysts have been reported in a small number of cases.Excision was performed in one patient because of symptoms of foreign body sensation. No treatment was indicated in the remaining cases.

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