Miscarriage: Predictive of Type 2 Diabetes?
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Later life diabetes risk was tied to a history of miscarriage, with what could be considered a dose response, according to a Danish study.

Women had a much higher chance of later developing type 2 diabetes if they had ever lost a pregnancy compared with women who had never experienced a pregnancy loss. As shown in their study online in Diabetologia, the chances of later developing diabetes increased if the woman lost more pregnancies compared with women who had been pregnant but never miscarried: One pregnancy loss: Odds ratio (OR) 1.18 (95% CI 1.13-1.23), Two pregnancy losses: OR 1.38 (95% CI 1.27-1.49), More than three pregnancy losses: OR 1.71 (95% CI 1.53-1.92).

For the analysis, the team compared data on nearly 25,000 Danish women with type 2 diabetes with about 250,000 controls free of diabetes; the women were matched based on age and education level.Among women who later developed diabetes, about 19%, 4%, and 2% had one, two, or at least three pregnancy losses, respectively. But among women who never developed diabetes, only 17%, 3%, and 1% of them lost one, two, or three or more pregnancies, and the link remained statistically significant after the researchers adjusted for obesity status and history of gestational diabetes.

Whether metabolic conditions at the time of pregnancy loss explain the association with type 2 diabetes or the association is caused by a shared etiology need to be explored in future studies.Additionally, women who were never able to achieve a pregnancy had the highest risk of subsequently developing diabetes. Compared with women who experienced any number of pregnancy losses, women who never achieved a pregnancy had a more than 50% higher chance of developing diabetes,

Source:https://www.medpagetoday.com/endocrinology/diabetes/86628
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