Misuse of steroid-based skin lightening products may cause h
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Topical corticosteroid misuse has previously been associated with several conditions and side effects like acne, skin thickening, perioral dermatitis, tinea incognito, pigmentation and cellulitis. Adrenal insufficiency is a condition in which the adrenal glands (a pair of glands located on top of the kidneys) do not make sufficient amounts of the hormone cortisol. As a result, the person may experience symptoms like low blood pressure, muscle pain, weakness, dizziness and weight loss. It also affects metabolism, immune function and inflammation.

However, corticosteroids are misused as skin lightening agents. For the study, a group researchers compared the baseline cortisol levels of 45 women who had been using topical cortisol for the last three months with those who were not using corticosteroid creams. It was found that women who were using creams with higher amounts of corticosteroids and those who were using the creams more frequently and on more areas of their body had lower cortisol levels. Those who used weaker strength creams did not have a major difference in their cortisol levels.

Since a lot of skin lightening creams are available over the counter and a lot of people are unaware of the side effects, they keep on using these creams. The study authors are also planning to extend their findings by studying a 24-hour urine test to find cortisol levels in the body, which is a much stronger indicator of adrenal function.

source: https://www.firstpost.com/health/misuse-of-steroid-based-skin-lightening-products-may-cause-hormonal-imbalances-heighten-adrenal-insufficiency-risk-8803621.html
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