Modafinil found to improve memory in people recovering from
A new study funded by the Medical Research Council (MRC) and Wellcome, and published in the journal Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, has found that the wakefulness-promoting drug modafinil improves memory functions in people recovering from depression.

This cognitive impairment tends to persist even in the recovery phase of depression when mood symptoms start to improve. People with persistent cognitive symptoms often then experience poorer outcomes such as impaired work functioning and are at increased risk for relapse.

The researchers found that participants who received modafinil made fewer errors in two specific types of memory, episodic memory and working memory, both of which are important in day-to-day activities. Episodic memory is used when remembering events such as where we left our keys in the house, or remembering where we parked our car, whereas we use working memory when we are rehearsing a new telephone number or when rehearsing a new passcode to access a computer network, for example.