Monocyte platelet aggregates present in children with Kawasa
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Platelet activation is an integral part of pathogenesis of Kawasaki disease (KD). Researchers aimed to analyse monocyte-platelet aggregates (MPAs), one of the sensitive markers for platelet activation, by flow cytometry in children with KD.

In this single-centre prospective study, 14 children with KD have been enrolled and results were compared with age-matched febrile (n=15) and healthy (n=13) controls. After gating monocytes in side-scatter plot, MPAs were identified based on CD14 and CD41 expression. 2 ml of blood samples for children with KD were collected at 3 phases of illness- acute stage before start of intravenous immunoglobulin or aspirin, 24 h after completion of IVIg infusion, and 3 months after acute episode of KD.

Results:
--Children with KD had a significantly higher MPA% values [Median (IQR)- 41.3%] when compared with febrile [Median (IQR)- 5.98%] and normal [Median (IQR)- 4.48%] controls.

--On follow-up, the MPA% showed a gradual decline in children with KD, but even at 3 months, the value [Median (IQR)- 7.55%] was higher compared to healthy controls [Median (IQR)- 4.48%].

In conclusion, these findings indicate that MPA% was significantly elevated in children with KD during acute stages, and that activated platelets may persist even after systemic inflammation has subsided.

Source: https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-021-00515-3
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