Mood disorders should be considered preexisting condition fo
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People with preexisting mood disorders had increased risk for COVID-19 hospitalization and death, according to results of a systematic review and meta-analysis published in JAMA Psychiatry. Thus, they should be categorized as an at-risk group on the basis of a preexisting condition, researchers suggested.

Researchers sought to determine the role of preexisting mood disorder in risk for COVID-19 susceptibility, hospitalization, severe complications and death. They systematically searched several databases from database inception to Feb. 1 for studies that reported data on COVID-19 outcomes among populations with and without mood disorders. They included 21 primary research articles involving more than 91 million individuals that featured quantitative COVID-19 outcome data from people with mood disorders compared with people without mood disorders of any age, sex and nationality.

People with preexisting mood disorders had significantly increased risk for COVID-19 hospitalization and death compared with people without mood disorders. The team found no association between mood disorders and COVID-19 susceptibility or severe events. They noted the presence of publication bias according to visual inspection of the composite funnel plot for asymmetry; however, the Egger regression intercept test result was not statistically significant.

“Individuals who have chronic mental disorders like depression need to be prioritized and provided with education around the importance of receiving the vaccine for their protection as this is an important pre-existing condition putting them at greater risk from COVID-19,” the researcher said.