More Than Half Of Patients Recovered From COVID-19 Complain
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In a major study, the researchers have shown that persistent fatigue occurs in more than half of patients recovered from COVID-19, regardless of the seriousness of their infection.

"While the presenting features of SARS-CoV-2 infection have been well-characterised, the medium and long-term consequences of infection remain unexplored," said study author Liam Townsend from St James's Hospital in Ireland.

For the study, the research team used a commonly-used scale to determine fatigue in recovered patients, called the Chalder Fatigue Score (CFQ-11).

They also looked at the severity of the patient's initial infection (need for admission, and critical/intensive care), and also their pre-existing conditions, including depression. They also looked at various markers of immune activation (white cell counts, C-reactive protein, Interluekin-6, and sCD25).

The study included 128 participants (mean age 50 years; 54 percent female) who were recruited consecutively at a median of 10 weeks following clinical recovery from SARS-CoV-2 infection.

More than half reported persistent fatigue (52.3%) at this point. The researchers offered an outpatient appointment to anyone who had a COVID-19 positive swab test in their laboratory at St James Hospital.

Of the patients assessed in this study, 71/128 (55.5 percent) were admitted to the hospital and 57/128 (44.5 percent) were not.

"Fatigue was found to occur independent of admission to hospital, affecting both groups equally," Townsend explained.

There was no association between COVID-19 severity and fatigue following COVID-19. Additionally, there was no association between routine laboratory markers of inflammation and cell turnover or pro-inflammatory molecules (IL-6 or sCD25) and fatigue post-COVID-19.

This study highlights the importance of assessing those recovering from COVID-19 for symptoms of severe fatigue, irrespective of the severity of initial illness, and may identify a group worthy of further study, and early intervention.

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