More Time Spent In Low Blood Sugar Range Tied To Poorer Mood
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This study aimed to investigate the impact of time in range (TIR) on mood in adults with type 1 diabetes (T1D).

Researchers followed a cohort of 219 T1D adults, all currently employing a real-time continuous glucose monitoring system, RT-CGM, to investigate how daily changes in CGM metrics were associated with nightly reports of positive and negative mood over a two-week period.

Results:
-- Greater daily %TIR (70–180 mg/dL) and less time in “severe” hyperglycemia (% time above range (TAR) more than 300 mg/dL) were both significantly associated with higher ratings on all positive mood elements and lower ratings on most negative mood elements.

-- When entered together as predictors, %TIR but not %TAR more than 300 emerged as an independent predictor of many of the positive and negative mood variables.

-- Neither daily changes in time spent in hypoglycemia (less than 70 mg/dL) nor glycemic variability (represented by the coefficient of variation) were significantly related to reported mood.

Conclusively, this study provides the first evidence that time in range (%TIR) is associated with, and likely enhances, daily mood. Consistent with previous studies, it also found that more time spent in “severe” hyperglycemia is linked to more negative mood.

Source: https://www.sciencedirect.com/science/article/abs/pii/S1056872720305274
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