Most Hospitalized COVID Patients Have Neurologic Symptoms
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More than half of COVID-19 patients admitted to two hospitals in Spain developed some form of neurologic symptoms. Neurologic manifestations were seen in 57.4% of 841 patients hospitalized with COVID-19 in March, researchers reported in a recent article published in Journal Neurology.

This is the largest hospital-based study of COVID-19 patients to analyze neurologic symptoms systematically.

Across all 841 hospitalized COVID-19 patients, myopathy (3.1%), dysautonomia (2.5%), cerebrovascular diseases (1.7%), seizures (0.7%), and hyperkinetic movement disorders (0.7%) occurred. Cerebrovascular diseases included 11 patients (1.3%) with ischemic stroke and three patients (0.4%) with intracranial hemorrhage.

In the study, nonspecific symptoms such as myalgias (17.2%), headache (14.1%), and dizziness (6.1%) were common. Anosmia (4.9%) and dysgeusia (6.2%) tended to occur early -- 60% of the time they occurred, they were the first clinical manifestation of COVID-19 -- and were more frequent in less severe cases. One case each of encephalitis, Guillain-Barré syndrome, and optic neuritis emerged.

"Moreover, there were some cases of otherwise unexplained vertebro-basilar dissection and also one case of multiple cortical hemorrhages associated with brain MRI pattern resembling posterior reversible encephalopathy syndrome," researchers added. "Although this study is mainly descriptive, it can be hypothesized that SARS-CoV-2 may carry special tropism towards posterior circulation and endotheliopathy may be suggested."

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