Mount Sinai's ‘MAGIC Algorithm’ can predict transplant patie
Researchers at Mount Sinai Health System have discovered a way to predict whether blood cancer patients who received a bone marrow transplant will develop graft-versus-host disease, a common and often lethal complication, according to a study published in JCI (The Journal of Clinical Investigation) Insight.

This international study at 11 cancer centers examined blood samples from almost 1,300 bone marrow transplant patients and found that two proteins present in blood drawn a week after a transplant can predict whether a patient will develop a lethal version of graft-versus-host disease, weeks before the disease's symptoms normally occur. Scientists at the Mount Sinai Acute GVHD International Consortium (MAGIC) created an algorithm, dubbed the "MAGIC algorithm," that determines a patient's risk of developing the disease by measuring concentrations of these proteins, ST2 and REG3a.

"The MAGIC algorithm gives doctors a roadmap to save many lives in the future. This simple blood test can determine which bone marrow transplant patients are at high risk for a lethal complication before it occurs," says James L.M. Ferrara, MD, Professor of Pediatrics, Oncological Sciences and Medicine, Hematology and Medical Oncology at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, and Co-director of MAGIC. "It will allow early intervention and potentially save many lives."

http://www.news-medical.net/news/20170209/New-e28098MAGIC-algorithme28099-can-predict-transplant-patiente28099s-risk-of-developing-graft-versus-host-disease.aspx
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