Multicentric Castleman's Disease in a Child Revealed by Chro
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Case Report
A 13-year-old girl with no past medical history, complained for 2 years of chronic diarrhea with no other clinical signs, and this has necessitated several visits to pediatricians without improvement under symptomatic treatment. Due to the persistence of diarrhea associated with growth retardation with a bone age corresponding to 10 years; celiac disease was suspected; antitransglutaminase and antiendomysium antibodies were negative; jejunal biopsy with histological study was read as villous atrophy II. The patient was put on gluten-free diet for 6 months without improvement. The evolution was marked by the persistence of diarrhea and the appearance of an intermittent fever, ranging between 37.8 and 38.5°C, asthenia, anorexia, weight loss, night sweats, and a deterioration of the general state. Second gastric and duodenal biopsies with histological study were read to show a nonspecific chronic interstitial duodenitis. The search of Koch's bacillus in sputum and tuberculin skin test was negative. Six months later, the patient developed insidiously growing abdominal mass; lymphoma was suspected, so she was transferred to our department for evaluation....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337035/
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