Multiple meningiomas in a patient with Cowden Syndrome
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Cowden syndrome is a rare, multisystem disease manifesting with increased hamartomas and neoplasms. Though meningioma has been documented in patients with Cowden syndrome, the relationship between these two phenomena is still unclear. We report a case of a 43-year-old female patient with a known PTEN mutation and clinical history of Cowden syndrome. A workup of a headache demonstrated two skull base meningiomas. At the time of surgery, several additional tiny meningiomas were detected in the same region. The development of multiple meningiomas in a patient with a predisposition for tumor is more than coincidental. Though PTEN mutations and deletions have not been shown to be critical for meningioma development.

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