Muscle Strength decreases over time in patients With Hypermo
Reduced maximal muscle strength and strength endurance have been found in patients with hypermobile Ehlers-Danlos syndrome/hypermobility spectrum disorder (hEDS/HSD) and are recognized as common associated features of the disorder. Therefore, the purpose of this 8-year follow-up study was to investigate the extent to which these parameters change over time.

30 female patients (mean age 41 years) with hEDS/HSD and 17 controls participated at baseline and 8 years later. Maximal muscle strength and strength endurance tests of the knee flexors and extensors, and 2 lower-extremity posture maintenance tests were performed to evaluate static strength endurance. In addition, muscle mass and density were evaluated by dual-energy x-ray absorptiometry and peripheral quantitative computed tomography.

--Maximal muscle strength and strength endurance were significantly lower at both baseline and follow-up in the hEDS/HSD group compared to the control group.

--Maximal muscle strength of the knee flexors (decreased in the control group), strength endurance of the knee extensors (decreased in the hEDS/HSD group and increased in the control group), and muscle density showed a significantly different evolution over 8 years. No other significant differences in evolution were found.

Conclusively, decreased muscle strength was identified at both time points in patients with hEDS/HSD. The evolution of most muscle strength parameters over time did not significantly differ between groups.