Musculoskeletal Manifestations of Pediatric ALL Delayed Diag
Presentation with musculoskeletal manifestations as the only symptom in pediatric B-cell acute lymphoblastic leukemia (ALL) was significantly associated with diagnostic delay, according to the results of a retrospective study published in the Journal of Pediatrics. However, this delay did not affect patient prognosis.

Musculoskeletal manifestations appear to be associated significantly with diagnostic delay but do not affect the oncologic outcomes of ALL,” wrote study author Seungcheol Kang, MD, of the department of orthopedic surgery at the Asan Medical Center Children’s Hospital in Korea, and colleagues. “Furthermore, given that the prevalence of malignancy among children presenting with musculoskeletal pain is extremely low, we believe that intensive hematologic evaluations for leukemia may be unnecessary for children who only present with limb pain, unless they also present with leukemic symptoms.”....