Myocardial infarction in monozygotic twins- A BMJ case repor
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
A 46-year-old man presented to the hospital with a brutal chest oppression with mandibular and left arm discomfort. He was a current smoker (28 pack-year) and his father had experienced a myocardial infarction. He was not receiving any medical treatment. The first ECG showed an inferior STEMI. Angiography revealed a mid-right coronary artery occluded by a thrombus, treated by angioplasty. He had an uneventful evolution after angioplasty in the coronary care unit and a normal left ventricular ejection fraction. His BMI was 26.6 kg/m2, his LDL cholesterol level was 121 mg/dL and triglyceride level was 233 mg/dL.

One year and 4 months later, his monozygotic twin brother was admitted to the hospital due to a sudden onset of chest pain and dyspnea. He was a former smoker (25 pack-year) taking aspirin and atorvastatin 10 mg since his brother’s infarction. The prehospital ECG showed an inferior STEMI. Coronary angiography disclosed mid-right coronary subocclusion and images suggestive of intracoronary thrombus.

Angioplasty was performed with a drug-eluting stent implantation in the mid-right coronary artery, followed by resolution of electrocardiographic signs and symptoms. His BMI was 25.2 kg/m2, LDL-C level was 51 mg/dL and triglyceride level was 260 mg/dL under atorvastatin. Lipoprotein (a) level was 124 mg/dL.

Both twin patients exhibited a very similar coronary artery disease, at the same age, with a very close coronary anatomy and an acute unstable coronary lesion in the mid-right coronary artery.

Learning points:
- There is a high concordance in coronary anatomy between monozygotic twins, between evident genetic factors and close environmental data.

- It reinforces the importance of primary prevention and thorough screening in twins’ siblings, when one is suspected of coronary disease.