Native valve fungal endocarditis caused by Aspergillus fumig
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Fungal endocarditis (FE) is a rare lethal inflammatory disease affecting the endocardium, including the heart valves. Neurological features, such as brain abscess, are known to manifest as complications of infective endocarditis (IE). Native valve FE caused by Aspergillus is uncommon and only a few cases have been reported in the literature, as it usually occurs in patients who have previously undergone valvular surgery.

Despite optimal therapeutic strategies, the survival rate remains low. FE is mostly caused by Candida albicans and Aspergillus fumigatus. Previous valvular surgery is the most essential risk factor for Aspergillus endocarditis, which observed in 40–50% of cases. However, native valve FE caused by Aspergillus is uncommon, with only a few reported cases. We hereby report a case of native valve FE caused by A. fumigatus with complications following Wegener’s disease and prostate cancer.

The patient survived after successful management with the combination of surgical and medical therapy. Aspergillus endocarditis is a rare and fatal fungal infection. Despite difficulties in diagnosis and treatment, medical intervention with antifungal therapy and immediate surgical intervention are essential to achieve desirable outcomes.

Source: https://academic.oup.com/omcr/article/2020/3/omz147/5813554
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