Needle-Based Confocal Laser Endomicroscopy
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Confocal laser endomicroscopy (CLE) is a newly developed endoscopic technique that enables imaging of the mucosal layer during endoscopy at a subcellular level of resolution. The method can therefore be used for the assessment of changes in vascular architecture, connective tissue, and cellular components in the mucosa, enabling endoscopists to collect real-time in vivo histological images or “optical biopsies” of the gastrointestinal (GI) mucosa during the endoscopy......

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672584/
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