Neither genetics nor social background is a very good predic
Genetic influences on BMI appear to markedly differ across life. Researchers used a birth cohort study to investigate differences in association and explained variance in polygenic risk for high BMI across infancy to old age (2–69 years). Data were from up to 2677 participants with measured BMI at 12-time points from 2–69 years. For polygenic liability to higher childhood, BMI explained variance was largest in adolescence and early adulthood; effect sizes were marginally smaller in absolute terms from adolescence to adulthood. All polygenic indices were related to higher variation in BMI; quantile regression analyses showed that effect sizes were sizably larger at the upper end of the BMI distribution. Socioeconomic and polygenic risk for higher BMI across life appear to operate additively; we found little evidence of an interaction. The findings highlight the likely independent influences of polygenic and socioeconomic factors on BMI across life. Despite sizable associations, the BMI variance explained by each plateaued or declined across adulthood while BMI variance itself increased. This is suggestive of the increasing importance of chance (‘non-shared) environmental influences on BMI across life.

Source: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010233
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