Neonatal Jaundice in Preterm Infants with Bilirubin Encephal
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The aim of this study is to clarify bilirubin parameters and its treatment in preterm infants with bilirubin encephalopathy (pBE).

The parameters used in the national survey were used to diagnose pBE. During the first 8 weeks of life, serum total bilirubin (TB), direct bilirubin (DB), albumin, and unbound bilirubin (UB) levels were assessed, as well as phototherapy and exchange transfusion treatments.

Results:
--Clinical data was obtained from 75 patients with pBE from 58 hospitals.

--The average peak TB level was 12.6 mg/dL (215 ?mol/L), and the average age at peak attainment was 19.7 days after birth.

--Albumin level was less than 2.5 g/dL in 44 patients, and the peak DB level was more than 2 mg/dL in 20 patients.

--The average peak bilirubin/albumin (B/A) (mg/g) ratio was 3.8, and the average age at peak attainment was 18.6 days.

--The average peak UB level was 0.67 ?g/dL (11.5 nmol/L). The median duration of phototherapy was 6 days, and the median day of the last session was 12.

--The peak TB level occurred after the last day of phototherapy in 30 of the 61 patients available for comparison.

Conclusively, Most patients with pBE lacked marked elevations in serum TB levels and the B/A ratio, the peaks of which were sometimes delayed to more than 4 weeks after birth.

Source: https://www.karger.com/Article/Abstract/513785
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