Neonatal MRI correlations and short-term and long-term neuro
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A Study was conducted to assess associations between neonatal brain injury assessed by magnetic resonance imaging and cognitive, motor, and behavioral outcomes at two and ten years of age, in a longitudinal cohort of children born very preterm.

112 children born at less than 32 weeks of gestation participated in a longitudinal prospective study on brain injury and neurodevelopmental outcome. Using the Kidokoro scoring, neonatal brain injury and altered brain growth in white matter, cortical and deep gray matter and cerebellum were assessed. Cognitive, motor, and behavioral outcomes were assessed during follow-up visits at both 2 (corrected) and 10 years of age.

--After adjusting for perinatal factors and level of maternal education, the global brain abnormality score was associated with cognition (B=-1.306), motor skills (B=-3.176) and behavior (B=.666) at 2 years of age, but was not associated with cognition at 10 years of age.

--In the subgroup of children with a moderate-severe global brain abnormality score, MRI was independently associated with cognitive impairment at 10 years of age.

--For children with milder forms of brain injury, only birth weight and level of maternal education were associated with cognitive outcomes.

Neonatal brain injury, measured by a standardised rating system, was correlated, in particular, with short-term neurodevelopmental effects, but only with childhood motor skills and actions. As children grow older, environmental factors, such as maternal education levels, become more important for cognitive development, especially for children with relatively mild neonatal brain injury.