Neuropathogenesis and Neurologic Manifestations of the Coron
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The review research, published in the Journal of the American Medical Association, noted the possible mechanism by which SARS-CoV-2 caused neurological symptoms by comparing it with similar coronaviruses MERS-CoV and SARS-CoV-1, which are known to affect the central nervous system (CNS).

Citing earlier research, published in the New England Journal of Medicine, they said neurologic symptoms reported in 49 of the study's 58 patients, including confusion and brain damage or encephalopathy.

Key Insights based on studies of MERS-CoV and SARS-CoV-1:

• Coronavirus may enter the nervous system by several routes, including via transfer across the junctions of infected neurons, and via the olfactory nerves connecting the nose and the brain.

• Virus may also infect the CNS by spreading across the inner walls of blood vessels throughout the body.

• Virus may also reach parts of the brain by infecting leukocyte which can cross the protective filter membrane called the blood-brain barrier.

• This "Trojan horse" mechanism of infecting the brain is seen in HIV, the scientists said.

• Most common neurologic complaints in COVID-19 are the loss of sense of smell and taste (anosmia and ageusia), headache, stroke, impairment of consciousness, seizure, and brain damage.

• However, the scientists said further studies involving brain scans and testing of CNS tissue will be crucial to understanding the biological process of the disease in the nervous system.

Source: https://jamanetwork.com/journals/jamaneurology/fullarticle/2766766
Dr. S●●●●●m S●●●●y P●●●●●l and 4 others like this4 shares
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Dr. S●●●●●m S●●●●y P●●●●●l
Dr. S●●●●●m S●●●●y P●●●●●l General Medicine
Interesting read. Does this indicate long term damage? We need answers as soon as possible.
Jun 3, 2020Like1