New Insights Into Preventing Herpes Infections
New insights into preventing herpes infections have been published in Nature Communications. Researchers from the Berlin Institute for Medical Systems Biology (BIMSB) at the MDC used single-cell RNA sequencing to better understand the viral infections.

Now a group of researchers is examining exactly what happens inside individual cells during an infection. The head of the team is Professor Markus Landthaler of the Berlin Institute for Medical Systems Biology (BIMSB) at the Max Delbrueck Center for Molecular Medicine (MDC). Molecular biologists and bioinformaticians work closely together here, and this also applies to Emanuel Wyler and Vedran Franke, the two lead authors of a new study on HSV-1 infections.

The study also presents another finding: A drug that is currently being tested for patients with chronic kidney disease could inhibit herpes infection by activating the NRF2 transcription factor. When the herpes virus enters host cells, it brings its own genetic information with it. This means that both human and virus genes are activated in the infected cells. When the team treated these cells with the kidney drug - bardoxolone methyl - the virus became less productive. It activated fewer of its own genes, which would normally fuel the infection. The authors believe this is due to the drug's effect on the NRF2 transcription factor.

Source: https://www.eurekalert.org/pub_releases/2019-10/mdcf-fth102419.php
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