New Strategies for Preventing and Healing Diabetic Foot
Foot ulcers are a particularly serious complication. If preventive measures are not adequately implemented, 5 to 10 diabetic patients in 100 will end up needing a lower limb amputation. These new approaches target two aspects of therapy: podiatric prevention and getting the ulcer to heal as quickly as possible to avoid infection.

Podiatric prevention consists of trying to stop the occurrence of an ulcer for patients at risk, most often those with peripheral neuropathy. "Smart mats," which are in development, detect minute differences in temperature between both feet that predict the short-term occurrence (within 40 days) of a foot ulcer. Preventive measures such as pedicures, prescription footwear, and the prevention of traumatic factors in the foot at risk can then be implemented.
New drugs mentioned an anti-PCSK9 lipid-lowering agent like evolocumab, rivaroxaban that has been proven to limit the development of occlusive arteritis of the lower limbs, reduce the major risk for limb amputation.

LeucoPatch, obtained from centrifuged blood, is applied directly to the ulcer, significantly improves the healing time. Local hyperbaric oxygen therapy is an even more recent topical treatment that also reduces healing time and promotes complete healing. Dressings with TLC-NOSF matrix technology make it possible to act on the factors that slow down healing.

Source: https://www.medscape.com/viewarticle/971844?src=rss
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