New drug candidate for the treatment of COVID-19 Identified
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Researchers have identified a drug with the potential to provide treatment for COVID-19.

The international team led by Professor Martin Michaelis found that the approved protease inhibitor aprotinin inhibited SARS-CoV-2 replication in therapeutically achievable concentrations.

Aprotinin inhibits the entry of SARS-CoV-2 into host cells and may compensate for the loss of host cell protease inhibitors that are downregulated upon SARS-CoV-2 infection.

Aprotinin aerosols are approved in Russia for the treatment of influenza and could be readily tested for the treatment of COVID-19.

Professor Martin Michaelis said: "The aprotinin aerosol has been reported to be tolerated extremely well in influenza patients. Hence, it may have a particular potential to prevent severe COVID-19 disease when applied early after diagnosis."

In conclusion, therapeutic aprotinin concentrations exert anti-SARS-CoV-2 activity. An approved aprotinin aerosol may have potential for the early local control of SARS-CoV-2 replication and the prevention of COVID-19 progression to a severe, systemic disease.

Source: https://www.mdpi.com/2073-4409/9/11/2377
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