New genetic immune disorder identified
Scientists have identified a new genetic immune disorder that is characterised by increased susceptibility to a virus associated to a type of cancer.
The researchers studied two unrelated sets of siblings with similar immune problems and determined their symptoms were likely caused by a lack of CD70, a protein found on the surface of several types of immune cells.
Both sets of siblings had evidence of uncontrolled infection with Epstein-Barr virus (EBV), a common and usually mild virus, which resulted in the development of cancer called Hodgkin’s lymphoma in three of these children.
Each child also had other immune symptoms, such as reduced activity of pathogen-fighting T cells, low production of antibodies and poor activation of antibody-producing B cells....
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