New genetic syndrome causing cancer identified
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Researchers at the University at Autonoma de Barcelona, in a study published in the journal Genetics in Medicine, have identified a new genetic syndrome that causes cancer. This syndrome is caused by mutations in both copies of the FANCM gene – also known as biallelic mutations that predispose the body to the early formation of tumours and chemotherapy toxicity.

They observed that there was an early onset of cancer and toxicity to chemotherapy, but the patients did not present any congenital malformations or haematological phenotype which could suggest being affected by Fanconi anaemia. Researchers at the Spanish National Cancer Research Centre (CNIO) confirmed that women with biallelic mutations in the FANCM gene did not develop Fanconi anaemia, but presented a higher risk of breast cancer, chemotherapy toxicity and chromosomal fragility. They hence suggested there is a need to modify the clinical monitoring of patients with biallelic mutations in the FANCM gene and taking precautions when using chemotherapy and radiation therapies due to the acute toxicity they may produce...

http://www.gulf-times.com/story/564878/New-genetic-syndrome-causing-cancer-identified
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