New imaging technique reveals individual RGCs
Scientists from the University of Rochester and University of Pittsburgh have developed a new imaging technique that captures individual neurons within the retinal ganglion cell (RGC) layer.

“In principle, this new approach might eventually allow us to detect the loss of single ganglion cells,” said David Williams, PhD, dean for Research in Arts, Sciences, and Engineering and the William G. Allyn Chair for Medical Optics at the University of Rochester. “The sooner we can catch the loss, the better our chances of halting disease and preventing vision loss.”

Imaging individual human RGCs has not been done before, in part because they are nearly perfectly transparent. In a study published this week in the Proceedings of the National Academy of Sciences, the researchers showed how they used an existing technology – confocal adaptive optics scanning light ophthalmoscopy – to collect multiple images and then combined those images in a technique called multi-offset detection....