New inhalation delivery system for vaccines
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Scientists have developed an inhalation delivery system for vaccines which generates potent immune responses in mice and non-human primates, without causing lung damage, an advance which may lead to new therapeutics for respiratory diseases like COVID-19.

The findings, published in the journal Med, suggests that a safe and effective lung delivery system could be developed for vaccines and therapeutics against pathogens such as the novel coronavirus.

"This translational strategy potentially enables more effective delivery of therapeutics or vaccines while reducing the chance of toxic side effects," said study co-author Wadih Arap from Rutgers Cancer Institute in the US.

According to the researchers, this mode of vaccine delivery has many advantages over other routes, particularly for the development of vaccines against respiratory infections as the therapeutics arrive directly at the site of the infection.

Inhalation-based vaccination is needle-free and minimally invasive, they said adding that it is especially attractive for administrating multiple doses.

The researchers said this method improves bioavailability and also reduces potential side effects by achieving a rapid onset of action.

The scientists believe lung delivery could protect against airborne pathogens that cause diseases such as tuberculosis, influenza, Ebola, measles, and COVID-19.

However, they said this approach has not been adopted widely, partly because the underlying physiological mechanisms remain largely unknown.

They said answering this question is critical for designing a general lung delivery system for widespread use.

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