New lung functions ...A surprising discovery
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Kaushalendra Tripathi
New lung functions ...A surprising discovery
The researchers unearthed this revelation unintentionally led by Professor Mark R. Looney , attempting to study how platelets circulating in the lungs interact with the immune framework in mice.To trace the cells’ path, the rodents had been genetically modified so that the platelets appeared a glowing green.

To the researchers' amazement, the lungs were loaded with megakaryocytes — the cells in charge of creating platelets. In spite of the fact that they have constantly known about the presence of these cells inside the lungs, they had trusted the numbers to be minor. Emma Lefrançais, who co-composed the review, says, "When we found this huge populace of megakaryocytes that had all the earmarks of being living in the lung, we understood we needed to take after this up."

Further examination uncovered that the megakaryocytes in the lungs were creating more than 10 million platelets, or the greater part the aggregate platelets, delivered by a mouse, each hour. They additionally saw the huge populace (1 million for every mouse lung) of blood stem cells ,
Looney said, "as far as anyone is concerned, this is the principal depiction of blood forebears inhabitant in the lung."

The researchers led three studies. Initially, they transplanted lungs from normal mice into the genetically engineered ones to analyze how the blood stem cells move throughout the body. By following the fluorescent cells, they discovered that megakaryocytes originate in the bone marrow but migrate to the lungs to produce platelets.

To test the practical applications of this discovery and see if it would be useful in the treatment of disorders like lung inflammation, Looney's group infused the fluorescent megakaryocyte cells into mice with low platelet count. To their joy, the transplanted cells got the opportunity to work quickly, reestablishing the platelet cell count to typical levels inside a brief span which was of great significance.

Finally, the researchers transplanted healthy lungs in which all the cells had been fluorescently tagged into mice whose bone marrow was not producing blood cells or platelets. The researchers found that the glowing green megakaryocyte progenitor cells instantly migrated from the lungs to the bone marrow, where they played a part in the production of platelets and other critical blood components, like neutrophils, B cells, and T cells.

Traci Mondoro from the US National Heart, Lung, and Blood Institute, says, "Looney and his group have upset some conventional thoughts regarding the pneumonic part in platelet-related hematopoiesis, preparing for further logical investigation of this incorporated science."

JOUNRAL ARTICLE :https://www.nature.com/nature/journal/v544/n7648/full/nature21706.html
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