New multiple sclerosis subtypes identified using artificial
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Scientists have used artificial intelligence (AI) to identify three new multiple sclerosis (MS) subtypes. Researchers say the groundbreaking findings will help identify those people more likely to have disease progression and help target treatments more effectively.

Multiple sclerosis (MS) can be divided into four phenotypes based on clinical evolution. The pathophysiological boundaries of these phenotypes are unclear, limiting treatment stratification. Machine learning can identify groups with similar features using multidimensional data.

For this study, published in Nature Communications, researchers wanted to find out if there were any—as yet unidentified—patterns in brain images, which would better guide treatment choice and identify patients who would best respond to a particular therapy.

Here, to classify MS subtypes based on pathological features, researchers apply unsupervised machine learning to brain MRI scans acquired in previously published studies. They use a training dataset from 6322 MS patients to define MRI-based subtypes and an independent cohort of 3068 patients for validation.

Based on the earliest abnormalities, investigators define MS subtypes as cortex-led, normal-appearing white matter-led, and lesion-led. People with the lesion-led subtype have the highest risk of confirmed disability progression (CDP) and the highest relapse rate. People with the lesion-led MS subtype show positive treatment responses in selected clinical trials.

The findings suggest that MRI-based subtypes predict MS disability progression and response to treatment and may be used to define groups of patients in interventional trials.

Dr. R●●a L●●●y
Dr. R●●a L●●●y Hepatobiliary Surgery
I was diagnosed with multiple sclerosis (MS). My vision was blurred for three months. I had closed my fingers in my front door without realizing it. I knew then something was wrong. I called my primary doctor who examined me and then sent me to the hospital. An MRI was performed and I was diagnosed with MS. I have been on World Herbs Clinic, MS HERBAL FORMULA for two month plus now, all my symptoms has decline completely, i feel normal again, but i have few weeks left completing the treatment.... Read more
Apr 14, 2021Like