New options under study, but for now anti-VEGF monotherapy r
Anti-VEGF-A therapy will never completely go away for the treatment of neovascular age-related macular degeneration, but new therapies that improve the efficacy and durability of treatment are needed to help bridge the results between clinical data and real-life results for patients.

VEGF-A suppression will not be abandoned, but researchers and ophthalmologists need to find a new way to increase efficacy and the durability of treatment to better serve patients diagnosed with wet AMD, OSN Retina/Vitreous Board Member Pravin U. Dugel, MD, said.

“I do think it’s important to recognize that VEGF-A suppression will never go away. It will always be the crux of our treatment strategy. If the Ophthotech study and the Regeneron study teach us anything, they teach us what a very high hurdle we must overcome to do better than anti-VEGF-A monotherapy. ... I think there is great opportunity to add on another agent for combination therapy that will either get us a greater durability or greater efficacy, and either of those two, but particularly both of those two, will help us close the delta,” Dugel said.