New perspective for pain control in Neonates, finds Study
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A Study was conducted to compare sucrose 24% oral gel formulation to liquid formula and breastfeeding during a heel prick in neonates that shows effeciency with the sucrose 24% gel.

In this comparative effectiveness research 195 neonates more than 36 weeks gestation were randomised to three groups, receiving during heel stick: (i) breastfeeding, (ii) sucrose 24% liquid with non-nutritive sucking and (iii) sucrose 24% gel with non-nutritive sucking. The pain was assessed through the Neonatal Infant Pain Scale.

Results:
--All the methods analysed has shown to be effective in reducing pain.

--There was an increase in odds of pain following liquid sucrose compared to breastfeeding (OR=1.60).

--A reduction of odds of pain was showed comparing sucrose to breastfeeding (OR=0.78), and comparing sucrose gel to liquid formula (OR=0.48).

Conclusively, Sucrose 24% gel with non-nutritive sucking seems to be a valid alternative when breastfeeding is not possible.

Source: https://www.nature.com/articles/s41372-021-01025-6
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