New study supports MET for larger ureteric stones
“Alpha-blockers appear to be efficacious in the management of patients with ureteral stones who are eligible for a trial of conservative management, and the benefit appears to be greater to those patients who have larger stones,” first author John M. Hollingsworth, MD, of the University of Michigan Medical School, Ann Arbor told Urology Times.

A 2015 multicenter study in The Lancet (2015; 386:341-9) had questioned the benefit of off-label alpha-blocker use and drew debate around the urologic community. Looking at 1,136 subjects in the United Kingdom, the study found no difference between medical expulsive therapy and placebo. However, a high rate of spontaneous stone passage among controls might better explain those results, Dr. Hollingsworth said....