New technique could enable safer production of polio vaccine
A new method to produce a stable fragment of poliovirus could enable safer production of vaccines, according to a study published in PLOS Pathogens.

Polio is almost completely eradicated, but polio vaccines are still needed to protect against the possibility of re-emergence. However, existing vaccine production methods require growing live viruses, which poses safety risks.

Previous research suggested that the empty protein shell of poliovirus has the potential to serve as an effective vaccine, and it can be produced without growing live viruses. However, these shell particles were too unstable to be practical for use as vaccines.

Now, Helen Fox and colleagues at the National Institute for Biological Standards and Control, United Kingdom, have developed a new method to produce polio protein shells that are stable enough to consider using as vaccines....