New universal Ebola vaccine may fight all four virus species
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Potential universal vaccine for Ebola viruses that preclinical tests show might neutralize all four species of these deadly viruses infecting people in recent outbreaks, according to a study published in the Journal of Virology, by the American Society for Microbiology.

#Different Approach

- The researchers designed a bivalent, spherical Ebola virus-like particle (VLP) that incorporates two genetically diverse glycoproteins (one each from the Zaire Ebola virus and Sudan Ebola virus) on a spherical core.

- This approach will not cause illness in the recipient as the VLPs lack the genetic material and do not multiply. The vaccine works by stimulating immune responses against Ebola that generate virus-fighting antibodies to attack the different virus species.

- When the researchers administered their new Ebola VLP vaccine to appropriate animal models, it produced robust immune responses against the Ebola virus species known to be pathogenic in humans.

- Although the new vaccine uses glycoproteins from two Ebola virus species, it might work against all four known pathogenic Ebola viruses as responses to one of the glycoproteins generates cross-reactive responses against two other Ebola virus species.

The researchers emphasize that extensive additional preclinical testing of the prospective Ebola VLP vaccine is needed before it could potentially be tested in clinical trials.

Source: https://jvi.asm.org/content/94/9/e01884-19
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