No Benefit Of High Dose Amoxicillin With Clavulanate For Acu
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Researchers have recently found out that adults treated for clinically diagnosed acute sinusitis did not appear to benefit from taking high-dose compared with standard-dose amoxicillin plus clavulanate. Acute bacterial sinusitis is common but currently recommended antibiotic treatment provides minimal benefit.

The study looked at adults prescribed amoxicillin plus clavulanate for acute bacterial sinusitis. 157 of a projected 240 participants had been enrolled, with 79 randomized to the standard dose and 78 to the high dose. Amoxicillin 875 mg with clavulanate 125 mg plus either placebo or amoxicillin 875 mg twice a day for 7 days were the interventions planned.

The primary efficacy outcome was a global rating of a lot better or no symptoms at the end of 3 days of treatment using a Global Rating of Improvement scale, with outcomes ranging from 1 to 6. The primary adverse effect outcome was severe diarrhea at 3 or 10 days after the start of treatment.

The following results were observed:

a. At day 3, 31 of 70 participants in the standard-dose group reported a global rating of "a lot better" or "no symptoms," as did 24 of 66 in the high-dose group, for a difference of ?7.9% .

b. Diarrhea was common in both groups by day 3, with any diarrhea reported in 29 of 71 participants (40.8%) receiving the standard dose and 28 of 65 (43.1%) receiving the high dose and severe diarrhea reported in 5 of 71 (7.0%) and 5 of 65 (7.7%), respectively.

Hence, the authors concluded that "adults treated for clinically diagnosed acute sinusitis did not appear to benefit from taking high-dose compared with standard-dose amoxicillin plus clavulanate."

Source;
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2777780?resultClick=3
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