No particular pharmacologic treatment observed in functional
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A Study was conducted to systematically review the efficacy and safety of the pharmacologic treatments available for pediatric FAPDs.

If the researchers looked at a study population of children (4–18 years old) with FAPDs who were treated with pharmacologic therapies and compared them to placebo, no therapy, or any other agent, RCTs or systematic reviews were included. Data extraction and quality assessment were completed separately by two reviewers. A third investigator resolved any interresearcher differences in the assessments.

Results:
--17 articles representing 1197 children with an FAPD were included.

--Trials investigating antispasmodics, antidepressants, antibiotics, antihistaminic, antiemetic, histamine-2-receptor antagonist, 5-HT4-receptor agonist, melatonin, and buspirone were included.

--No studies were found on treatment with laxatives, antidiarrheals, analgesics, antimigraines, and serotonergics.

To summarize, no single pharmacologic medication can be recommended for the treatment of juvenile FAPDs. Antispasmodics and antidepressants, on the other hand, can be considered in daily practice due to their positive treatment outcomes and lack of significant side effects. To offer adequate pharmacologic treatment, high-quality RCTs are required.

Source: https://pediatrics.aappublications.org/content/early/2021/05/26/peds.2020-042101?rss=1
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