No relevant Health Outcomes seen in Young Children Following
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The long-term protection of Tdap vaccination during pregnancy was investigated by researchers. Tetanus, diphtheria, and acellular pertussis vaccine (Tdap) is routinely prescribed as a method to protect young babies against serious pertussis infection in many countries. Few studies have looked at whether vaccine exposure during pregnancy is linked to long-term negative health effects in children.

To determine study outcomes, all live births between April 2012 and March 2017 were included, and children were monitored for up to 6 years. At a 1:5 ratio, children exposed to prenatal Tdap were propensity score matched to children who had not been exposed. Vaccine-specific fee codes were used to determine Tdap vaccination during pregnancy. From birth to the end of follow-up, immune-related (infectious diseases, asthma) and nonimmune-related (neoplasm, sensory disorders) outcomes, as well as a nonspecific morbidity outcome (urgent or inpatient health care use), were assessed.

Results:
--Of 625643 live births, 12045 were exposed to Tdap in utero.

--There were no significant increased risks of adverse childhood outcomes and prenatal Tdap exposure; however, researchers observed inverse associations with upper respiratory infections (0.94), gastrointestinal infections (0.85), and urgent and inpatient health service use (0.93).

Finally, Tdap vaccination during pregnancy was not linked to an increased risk of adverse health effects in early childhood, indicating that Tdap vaccination during pregnancy is Safe in the long run.

Source: https://pediatrics.aappublications.org/content/147/5/e2020042507?rss=1
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