No signficant relation found between Rheumatoid Arthritis in
A Study was conducted to examine the overall cognitive development of children exposed to maternal rheumatoid arthritis (RA) in utero by comparing their school test scores to those of their peers.

738,862 Children were included. Children exposed to maternal RA were identified through linkage of national registers. In separate analysis, exposure was subdivided according to maternal serostatus. Preclinical maternal RA was included as a separate exposure.

The Danish national school tests are mandatory standardized tests. Results from all reading tests (grades 2, 4, 6, and 8) and mathematics tests (grades 3 and 6) were included. Test scores were compared according to maternal RA exposure for each test separately using linear regressions.

--934 children exposed to maternal RA in utero were identified. There were no differences in reading test scores between maternal RA exposed and unexposed children.

--RA exposed children scored poorer in both mathematics tests (adjusted differences of mean score –0.14 SD and –0.16 SD.

--There was no appreciable difference between children by maternal RA serostatus. Children exposed to preclinical RA (n = 589) showed the same pattern of performance as children exposed to RA.

Conclusively, children exposed to RA were slightly poorer in the math exams, but also fared in the reading tests as were their unexhibited counterparts. The data show no significant impact on children's school performance during pregnancy.