Nobel Prize Winner Barry J. Marshall in part proved what cau
Links between H. Pylori and ulcers had been suggested as early as 1940 by Dr. A. Stone Freedberg, a cardiologist from Harvard. But he gave up his research after facing overwhelming opposition from his peers. The prevailing wisdom was stress, spicy food and too much acid leads to stomach ulcers.

Barry Marshall’s first significant encounter with stomach ulcers was while training to become a specialist in gastroenterology. In 1984, he unsuccessfully attempting to infect an animal model. There was interest and support from a few but most of his work was rejected for publication and even accepted papers were significantly delayed. At the same time he was successfully experimentally treating patients who had suffered with life threatening ulcer disease for years. Some of his patients had postponed surgery which became unnecessary after a simple 2 week course of antibiotics and bismuth. He had developed his hypothesis that these bacteria were the cause of peptic ulcers and a significant risk for stomach cancer.

Even though Marshall was absolutely convinced the bacteria caused stomach ulcers, he couldn’t test his theory on humans which is why, on June 12, 1984, Marshall finished his workday after drinking the bacteria! ' Scientists who test their theories on themselves invariably become either superheroes or supervillains', he said. Just a few days later he developed ulcers for the first time in his life.

A decade later, in 1994, National Institutes of Health (NIH) announced “the key to treatment of duodenal and gastric ulcer was detection and eradication of Helicobacter pylori.” 11 years later, in 2005, he was given a Nobel prize for his work

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