Non-alcoholic fatty liver disease in pregnancy is associated
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Highlights of the study
- The prevalence of non-alcoholic fatty liver disease (NAFLD) has nearly tripled over the past decade.
- Maternal and perinatal complications are more common in mothers with NAFLD than in those with other liver diseases.
- NAFLD in pregnancy is independently associated with adverse maternal and perinatal outcomes.
- Women with NAFLD warrant pre-conception counseling and may benefit from high-risk obstetrics management during pregnancy

The prevalence of non-alcoholic fatty liver disease (NAFLD) in pregnancy has almost tripled over the past 10 years. Having NAFLD during pregnancy increases risks for both the mother and the baby, including hypertensive complications of pregnancy, bleeding after delivery, and preterm birth. Thus, preconception counseling is warranted with consideration of highrisk obstetric management among women with NAFLD in pregnancy.

Among 18,574,225 pregnancies, 5,640 had NAFLD and 115,210 had other, non-NAFLD CLD. Compared to the other groups, patients with NAFLD during pregnancy more frequently experienced gestational diabetes, hypertensive complications, postpartum hemorrhage, and preterm birth.

Conclusively, the prevalence of NAFLD in pregnancy has nearly tripled in the last decade and is independently associated with hypertensive complications, postpartum hemorrhage, and preterm birth. NAFLD should be considered a high-risk obstetric condition, with clinical implications for pre-conception counseling and pregnancy care.

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