Non-hospitalised COVID Patients Have Low Risk Of Serious Lon
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Non-hospitalised COVID-19 patients have a low risk of serious long-term effects, but they report more visits to general practitioners following infection, according to a study. Individuals admitted to hospital for COVID-19 might have persisting symptoms and delayed complications after discharge. However, little is known regarding the risk for those not admitted to hospital. The team therefore examined prescription drug and health-care use after SARS-CoV-2 infection not requiring hospital admission.

This was a population-based cohort study. All individuals with a positive or negative RT-PCR test for SARS-CoV-2 in Denmark between Feb 27 and May 31, 2020, were eligible for inclusion. Outcomes of interest were delayed acute complications, chronic disease, hospital visits due to persisting symptoms, and prescription drug use.

The team used data from non-hospitalised SARS-CoV-2-positive and matched SARS-CoV-2-negative individuals from 2 weeks to 6 months after a SARS-CoV-2 test to obtain propensity score-weighted risk differences (RDs) and risk ratios (RRs) for initiation of 14 drug groups and 27 hospital diagnoses indicative of potential post-acute effects. We also calculated prior event rate ratio-adjusted rate ratios of overall health-care use.

Results:
10498 eligible individuals tested positive for SARS-CoV-2 in Denmark from Feb 27 to May 31, 2020, of whom 8983 (85·6%) were alive and not admitted to hospital 2 weeks after their positive test. The matched SARS-CoV-2-negative reference population not admitted to hospital consisted of 80894 individuals.

Compared with SARS-CoV-2-negative individuals, SARS-CoV-2-positive individuals were not at an increased risk of initiating new drugs except bronchodilating agents, specifically short-acting 2-agonists. There was an increased risk of receiving hospital diagnoses of dyspnoea and venous thromboembolism for SARS-CoV-2-positive individuals compared with negative individuals.

Prior event rate ratio-adjusted rate ratios of overall general practitioner visits and outpatient hospital visits, but not hospital admission, showed increases among SARS-CoV-2-positive individuals compared with SARS-CoV-2-negative individuals.

Conclusion:
The absolute risk of severe post-acute complications after SARS-CoV-2 infection not requiring hospital admission is low. However, increases in visits to general practitioners and outpatient hospital visits could indicate COVID-19 sequelae.

Source:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00211-5/fulltext
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