Nonalcoholic fatty liver disease in children with obesity: C
Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease among children, due to increase in the number of obese children around the world. Since NAFLD is asymptomatic in its early stages, it is important to understand the risk factors for prevention in children. The aim of this study was to look at potential NAFLD risk factors in obese children and provide evidence for early screening and preventive strategies for obese children with NAFLD.

Data were collected from 428 children and adolescents aged 6-16 years. Based on a combination of ultrasound results and alanine transaminase levels, subjects were divided into three groups:
1) Simple obesity (SOB),
2) Simple steatosis (SS), and
3) Nonalcoholic fatty hepatitis (NASH).
Blood biochemical examination included glucose, insulin, uric acid, lipid profile and liver enzymes.

Results:
--Among 428 children with obesity, 235 had SS and 45 had NASH.

--Body mass index, body mass index standard deviation score (BMI-SDS), waist circumference, body fat, liver enzymes, uric acid and HOMA-IR level were significantly higher in the NASH group than in the SS and SOB groups.

--53.3% of the SS group and 49.8% of the NASH group had metabolic syndrome, significantly more than in the SOB group.

--After adjustment for confounding factors, logistic regression models revealed that NASH was associated with BMI-SDS more than 3, gender, hyperuricemia and insulin resistance.

In particular, high BMI-SDS, gender, insulin resistance, and hyperuricemia are all linked to the prevalence of NASH in obese children. These results show that tracking childhood obesity risk factors will aid in the development of early-stage liver disease prevention strategies.

Source: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-021-02595-2
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