Noninvasive Prediction of Occult Peritoneal Metastasis in Ga
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Occult peritoneal metastasis frequently occurs in patients with advanced gastric cancer and is poorly diagnosed with currently available tools. Because the presence of peritoneal metastasis precludes the possibility of curative surgery, there is an unmet need for a noninvasive approach to reliably identify patients with occult peritoneal metastasis.

The objective of the study was to assess the use of a deep learning model for predicting occult peritoneal metastasis based on preoperative computed tomography images.

Data from a cohort of 1225 patients with gastric cancer who underwent surgery at Sun Yat-sen University Cancer Center (Guangzhou, China) were used for training purposes. To externally validate the model, data were collected from 2 independent cohorts comprising a total of 753 patients with gastric cancer who underwent surgery at Nanfang Hospital or the Third Affiliated Hospital of Southern Medical University. The status of peritoneal metastasis for all patients was confirmed by pathological examination of pleural specimens obtained during surgery.

A total of 1978 patients were included in the study. The PMetNet model achieved the area under the receiver operating characteristic curve (AUC) of 0.946, with a sensitivity of 75.4% and a specificity of 92.9% in external validation cohort 1. In external validation cohort 2, the AUC was 0.920, with a sensitivity of 87.5% and a specificity of 98.2%. The discrimination performance of PMetNet was substantially higher than conventional clinicopathological factors (AUC range, 0.51-0.63). In multivariable logistic regression analysis, PMetNet was an independent predictor of occult peritoneal metastasis.

Conclusively, the findings of this cohort study suggest that the PMetNet model can serve as a reliable noninvasive tool for early identification of patients with clinically occult peritoneal metastasis, which will inform individualized preoperative treatment decision-making and may avoid unnecessary surgery and complications.

Jama network open
Source: http://jamanetwork.com/article.aspx?doi=10.1001/jamanetworkopen.2020.32269
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